Book reviews - Pesticides News No.35

Corporate information up date

Agrow’s annual survey of the top 25 agrochemical companies indicates that the top eleven remain the main European and US companies, with Ciba Geigy still the market leader, but Monsanto now in second position, followed by Zeneca.

These eleven companies account for 81% of global sales. Concentration in the market has become even greater since this analysis, which covers the 1995 financial year, with the consolidation of Ciba-Geigy and Sandoz (No. 11 in 1995) to form Novartis. The eight Japanese companies in the top 25 together account for 13.6% of sales.
    The 1995 financial year was very profitable, with sales increases in real terms of 4.3%, and total end-user sales of nearly US$29,000 million (other industry analysts had put it slightly higher). Herbicides account for 48% of sales, followed by insecticides with 27% and fungicides 19%. Three companies dominate the world herbicide market: Ciba Geigy; Monsanto, with glyphosate—the world’s biggest selling pesticide—accounting for 65% of its total pesticide sales; and Zeneca, with paraquat still a major money-spinner. Insecticides are dominated by Bayer, with over 10% of the world market and fungicides again by Ciba with over 15% of the market.
    One surprise entry is the New Zealand company Fernz, the generic pesticide producer trading as Nufarm, which became the 24th largest company: but its share of less than 1% of global sales is no threat to the present pecking order. The other non-European/US/Japanese company is the Israeli firm Makhteshim Agan, which concentrates mainly on generics.

Biotechnology focus
Biotechnology is a key interest of all the major R&D-based companies, most of which are involved in herbicide-tolerant research. The aim of the companies is to cement profits from the expanding herbicide market and continue to influence a high-input, industrial agriculture strategy.
    With the world’s top-selling pesticide, Monsanto is also a leading company introducing transgenic crops, for obvious reasons focusing on glyphosate-tolerant crops, including soybeans, canola, oilseed rape, cotton, sugar beet and maize. The glyphosate market is already estimated at over US$1,800 million, or 6% of all agrochemical sales. In the next five years—and encouraged by glyphosate-tolerant crops—farmers could be applying 40,000 tonnes of this active ingredient to their crops. Monsanto is also investigating plants expressing traits of the bio-insecticide Bacillus thuringiensis (Bt). Monsanto is determined to prevent farmers from saving seeds and replanting by ensuring all its transgenic crops are hybrid varieties which will not breed true.
    Zeneca is on target to be the major seed producer by the end of the century. It has merged its seed business with a Dutch company to form Zeneca VanderHave, and became one of the top five seeds companies with annual sales of around US$460 million. The company is looking for proteins with fungicidal activities in seeds. An interesting development in Zeneca is research into transgenic trees with Nippon Paper Industries and Shell, to produce certain trees for paper production with lower energy and bleach input.
    Zeneca has developed maize and oilseed rape tolerant of AgrEvo’s herbicide, glufosinate. AgrEvo is also focusing on glufosinate-tolerant crops, such as ‘Liberty Link' oilseed rape, resistant to up to 6-8 times the normal dose of glufosinate. It is also developing maize—and soybean-tolerant glufosinate as well as plants resistant to fungal and viral attack.
     DowElanco is consolidating its seeds and biotech interests, and in a deal with Mycogen (US), exchanged its seed business for a 46% stake in Mycogen. Biotechnology in DowElanco focuses on major crops, especially maize.
    BASF is using biotech fermentation methods to produce active isomers of mecoprop and dichlorprop herbicides, and has agreements to introduce maize tolerance to its sethoxydim based herbicides: it predicts planting may increase 15-20 times to 3-4 million acres in the next two years.
    Ciba Geigy is focusing on transgenic crops that express improved or enhanced natural resistance, but has earned criticism from environmental groups for its maize which expresses Bacillus thuringiensis (Bt) offering resistance to corn borer attack. Ciba Geigy is supplying the International Rice Research Institute, IRRI, with its proprietary Bt endotoxin gene to enable it to produce a transgenic rice. Cyanamid is experimenting with genetically engineered baculovirus, Autographa californica multiple nuclear polyhedrosis virus (AcMNPV), against Lepidopterous pests in cotton, tobacco and leafy vegetables, containing an insect specific neurotoxin from a scorpion, which is also a focus of Du Pont’s biotech research.
    Rhône Poulenc has interests in biotechnology including tolerance to its own herbicide, bromoxynil. It has released bromoxynil-tolerant tobacco and cotton and is investigating transferring the gene into potatoes and oilseed rape. Bayer is concentrating on improving crop resistance to pests and diseases, biological crop protection and herbicide-tolerant crops. Cyanamid is focusing on imidazolinone-tolerant soybeans and leguminous crops (IMI-crops) and is developing a new herbicide for use in IMI-crop varieties.

Japan
Nearly all companies are seeking to gain access to the huge Japanese rice market, and the growing distribution networks of Japanese companies. AgrEvo has signed an agreement with ISK to sell glufosinate in Japan, hoping it will extend later to other products. Ciba Geigy is targeting Japanese rice sales and has entered a joint venture with Japanese Mitsui Toatsu and increased its stake in Tomono Agrica (Japan) from 20% to 50%. DowElanco also has a joint venture in Japan.

Eastern Europe and China
In Eastern Europe, Rhône Poulenc is leading a joint venture in Kazakhstan with the Kyrgyz Agribusiness Co, aiming to make the country self-sufficient in cereals by an agrochemical-based strategy to doubling yields from the current 2.5 tonnes per ha. AgrEvo has just joined this venture. BASF has expectations that the Eastern European market will recover, and is building a presence in each of the Eastern European countries, though the markets are still poor. It has one of the largest agrochemical marketing structures in place in the Russian Republic. Du Pont has important sales in Poland and Hungary.
    Zeneca, once geared up to invest in Eastern Europe, has been marking time, and has focused on China. China also interests AgrEvo, which has a joint venture with two Chinese companies, aiming to sell anilofos and endosulfan and Du Pont , which invested US$25 million in a Shanghai plant to produce bensulfuron-methyl, 80% owned by Du Pont.

Copping, LG, AGROW’s Top Twenty Five 1996, PJB Publications, 18-20 Hill Rise, Richmond, TW10 6UA, UK, 1996, 265pp.

 

Trends in pesticide application
Too little attention focuses on pesticide application, where sound technology can minimise waste, spray drift, efficacy and save farmers’ money. This new Agrow report provides a good overview of what is currently available in all areas of pest control, agriculture, horticulture, amenity use and public health. Nevertheless, it notes that application techniques have changed little over the last 100 years, although there have been improvements in the technology.
    This is a fairly uncritical survey of existing technology. For example, in looking at aerial spraying, it assumes that guidelines for farmers have eliminated many of the problems of overspraying, water-source contamination and spray drift associated with this application method. Nor does it acknowledge that problems with pesticide application may be addressed by non-chemical means. Dr Copping does, however, discuss frankly areas of conflict between farmers’ need to minimise pest damage, for example by spraying when spray drift is a problem, and health and safety regulations.
    This report is a useful overview of the existing state of application.

Copping, LG, Trends in Application Techniques, Agrow, PJB Publications, 18-20 Hill Rise, Richmond, TW10 6UA, UK, 1996, 121pp.

 

Marketing transgenic plants 
This important selection of papers—results from a workshop hosted by the Panamerican College of Agriculture Zamorano in May 1996—springs from a concern with the growth and availability in central America of crop plants which express pesticide characteristics. At present the most important transgenes are derived from soil bacterium and the bio-insecticide Bacillus thuringiensis (Bt). There is a real fear that the expansion of plants bred to contain the Bt gene will speed up insect resistance to this important pest control product. A possible ecological hazard lies in the potential for transgenic crops to create new weeds, and to erode genetic diversity by genetic exchanges with wild native plants. A recent study has shown that genes from a crop can move rapidly into wild, weedy relatives and create new weed species. Yet Latin America is not prepared for the entry of these new crops. With the exceptions of Mexico and Costa Rica, government officials, researchers, extension agencies, foreign donors, farmers and consumers are uninformed of the risks and benefits. Nor has the technology been analysed in the regional context to develop recommendations, policies, laws or regulations about its use. These papers are an important attempt to fill this void.

Hruska, Allan J and Milton Lara Pavón, Transgenic Plants in Mesoamerican Agriculture, Zamorano Academic Press, Librería Zamorano, Box 93, Tegucigalpa, MDC, Honduras, CA, 1997, 127pp.

 

Order direct from Amazon.co.uk

Global trends
The World Watch Institute has produced its annual Vital Signs 1996 which reports on a wide range of long-term global trends. It contains one report on the pesticides trade—'Efforts to Control the Global Pesticides Expand'  by Toni Nelson and another— 'Organic Farming Up Sharply' by Gary Gardner.
    Nelson predicts that sales are likely to increase and focuses on the negative costs of pesticides such as acute and chronic health effects. She reports on the efforts to control the use and trade of pesticides through the Prior Informed Control (PIC) procedure. She criticises PIC because it only contains 12 pesticides (now out of date see page 9), although some 127 chemicals are possible candidates for future inclusion.
    Gary Gardner says that output from organic farming is up sharply during the 1990s. Although global data are not available, several national and regional indicators reveal clear trends: organically cultivated area in the European Union expanded fourfold between 1987 and 1993. In the US, sales of organic farm products more than doubled between 1990 and 1994. The report focuses mostly on the US and Europe where most organic production occurs. One reference to Latin America does show that organic produce is increasingly seen as a lucrative niche market. Mexico, for example, is now the world's largest producer of organic coffee.

Brown, L, Flavin, C and Kane, H., Vital Signs 1996, World Watch Institute, 1776 Massachusetts Avenue, NW, Washington DC, 20036, US, 169pp. Order direct from Amazon.co.uk

 

Best control—wrong format?
The Best Control published on CD ROM is an electronic reference book on the best methods for controlling home and garden pests using integrated pest management (IPM) techniques. The premise of the book is that synthetic chemical pesticides are toxic and hazardous and there is generally no need to use them for the control of pests.
    This is a worthy and well argued stance, and The Best Control supports it by providing detailed instructions on the control of home and garden pests from ants to yellowjackets (wasps) and algae to weeds. Information about pests includes detailed physiological and ecological characteristics which are essential for effective IPM, and then practical prevention and control techniques are listed. The author is also an experienced pest controller and is therefore not just spouting ideological theory.
    This publication is not particularly easy to use despite its hi-tech format. First a relatively high degree of computer literacy is needed to load and run the necessary software. Secondly good quality hardware is needed in order to view the text and illustrations. Reading large amounts of text on a computer screen is not easy, and many of the illustrations are not  clear.
    The electronic format needs refinement to be really useful. It would be best to wait for the book.

The Best Control, Stephen Tvedten, Get Set Inc., 2530 Hayes St., Marne, MI 49435-9751, US. Usable on PC, Mac and UNIX computers.(also available in ring bound hard copy format).

 

Pesticide evaluations
Experts from the World Health Organisation and the Food and Agriculture Organisation  have assessed a number of pesticides in their series of toxicological and environmental monographs. The current volume examines benomyl, captan, carbendazim, fenarimol, fenpyroximate, fenthion, flusilazole, folpet, haloxyfop, iprodione, monocrotophos, parathion, parathion-methyl, piperonyl butoxide, quintozene, thiophanate-methyl, vinclozolin. It is a useful document containing much detailed information.

Pesticide residues in food—1995, Part II-toxicological and environmental, Joint FAO/WHO meeting on pesticide residues, International Programme on Chemical Safety, 1211 Geneva 27 Switzerland, WHO/PCS/96.48, 1996, 498pp.

 

Veterinary products data
The 1997-98 edition of the National Office of Animal Health (NOAH) Compendium of Data Sheets for Veterinary Products is now available. It gives data sheets on safety instructions, dosage rates. It contains details of pesticide products, such as organophosphates and synthetic pyrethroids, available for treatment against ectoparasites on domestic animals. A free copy is being sent to every UK veterinary surgeon.

Compendium of Data Sheets for Veterinary Products 1997-1998, NOAH, 3 Crossfield Chambers, Gladbeck Way, Enfield, EN2 7HF, UK, 1997.

 

Draft code of practice

The UK Code of Practice for the Safe Use of Pesticides on Farms and Holdings was first issued in 1990 and is now being revised. The consultation period lasts until 24 March. The Code is one of the essential documents on agricultural pesticide practice.
    The revised document briefly mentions ‘the principles of integrated control’ and the need to minimise pesticide use. It provides revised advice on how to conduct a risk assessment.
    Under information for the protection of the public, it reminds farmers of their responsibilities for ensuring proper warnings are given prior to pesticide application—these include notifying adjoining landowners, public rights of way, or vulnerable groups of people who may be exposed—e.g. spray which may affect hospitals, schools and old people’s homes.
    One of the best improvements is the proposal to make the revised Code available free.

Pesticides Safety Directorate, Room 317, Mallard House, Kings Pool, 3 Peasholme Green, York, YO1 2PX, UK.

 

US pesticide report
The US Office of Pesticide Programs (OPP) has produced its annual report for 1996.  As part of the US Environmental Protection Agency (EPA), OPP's mission is to protect human health and the environment from the risks posed by pesticides and to promote safer means of pest control.
    The report says in the US there are 620 active ingredients which make up 20,000 registered products. Pesticides sales are now $9 billion.
    During the year OPP established a permanent Biopesticides and Pollution Prevention Division. As a result, ten new biopesticides and associated products were registered (out of a total of 24 pesticides). One such example includes a nematode than can replace some uses of methyl bromide, an ozone delpleting conventional pesticide.

OPP Annual Report for 1996, US EPA, Washington DC, US, 45pp.

 

1,2-dibromoethane report
This report evaluates the risks to humans and the environment posed by 1,2-dibromo-ethane. It is used as a fumigant for soil, grains and fruits. Demand has been reduced substantially following bans on its use.
    In humans, 1,2-dibromoethane is strongly irritant to the eyes, skin and respiratory tract. Symptoms of poisoning are identified as headaches, severe vomiting, diarrhoea, respiratory tract irritation, and death is usually caused by pneumonia following damage to the lungs. Adverse effects on reproductive function have been observed in laboratory experiments. Strong evidence from animal studies also supports the conclusion that 1,2-dibromoethane is a potential human carcinogen.

1,2-dibromoethane, Environmental Health Criteria, No. 177, World Health Organisation, 1211 Geneva 27, Switzerland, 1996, 148pp.

[This article first appeared in Pesticides News No. 35, March 1997, pages 22-23]