Book reviews - Pesticides News No. 44

Visions of the food-biotech industry  
The four-yearly forum of the Congresses of Pesticide Chemistry held in 1998 focused on the theme of the ‘Food-Environment Challenge’.
   
Key papers have now been published, covering issues from the more policy end of the spectrum, to new chemistry, precision agriculture delivery of plant protection, pesticide resistance, environmental fate, residues in food and the environment, and regulation and risk assessment.
    Not all papers addressed biotechnology, but the theme pervaded the conference. A keynote paper by David Evans of Zeneca Agrochemicals started from the explicit position that pesticide technology has enabled food production to keep pace with population increases.  With world population estimated to reach 10 billion in 2040, Evans believes that biotechnology is essential to bring about the yield enhancement to deliver increased food production.  Although the main properties of biotechnology to date have focused on herbicide resistance and insect resistance, Evans projects that the future will see enhanced yields and food quality as the benefits. To develop the biotechnology products, he notes that companies want:  the gene, the technology the freedom to operate, access to leading germplasm, value protection and extraction.  
    A group of scientists from the US, Australia and Turkey, warns that public acceptance of GM foods will not be universal. They express concern that “recombinant methods are certain to disrupt current agricultural practice as have all previous technological innovations. With investment in agricultural research dropping in most countries—for example in the US government funding dropped by 30% in the last 25 years (and public sector investment by 14%)—there will be fewer public sector scientists to help agriculture adjust to these new tools.” GM technology seems certain to accelerate loss of agricultural germplasm. The paper notes a charge against agricultural biotechnology that it is producing toys for wealthy nations and profits for large companies, quoting one scientist who joined a company to make the ‘volkspotato’ to feed the world but is instead engaged in making the ‘yuppie potato’ optimized for fast food franchises.
    A paper by Alastair Robertson of the UK supermarket Safeway urges the pesticide industry to ‘maintain focus on the end consumer.’  While not rejecting biotechnology, the Safeway view is that greater technical competency is required of farmers to farm to more stringent standards and utilise new developments effectively and safely. Some concerns include future resistance to Bacillus thuringiensis and the need to ensure that GM crops can be segregated.
    In an interesting shift in perspective, David Evans notes that compared to the US$3,000 billion food industry, the agrochemical industry is relatively small, and concludes that the latter should see itself more as part of the food provision industry rather than the chemical industry. This is happening and has led to greater dialogue with the giants in food such as Unilever, Nestlé and Pepsi. Nestlé’s food sales are greater than food sale purchases in countries such as Mexico, Spain, Holland, Belgium and Australia. He notes too the shift in the pesticide industry as companies increase their vertical integration, particularly to take over—or in the case of Zeneca work in partnership—with the seeds companies (see page 7).
    Although Evans believes the present regulatory framework for pesticides is satisfactory,  James Hay of DuPont predicts that pesticide registration will become more stringent, requiring safer herbicides, based on natural products, and use of new chemistry. Advances in technology mean that with new ‘combinatorial techniques’ (mixtures) a single chemist can synthesise hundreds of thousands of novel compounds a year, compared to around 10,000 in the past. These tools mean that a much wider range of molecules can be tested to find new classes of compounds that target new classes of proteins in plant and pathogen genomes.
    In dealing with more traditional concerns of pesticides residues in food, Ian Shaw presented a paper on variations in standards of monitoring foods for pesticide residues. The  European Union instituted a monitoring exercise on residues, asking Member States to test for seven individual pesticides and two groups of pesticides on five commodities. The results showed residue levels were reasonably consistent and comparable with other industrialised countries. The exercise represented a small percentage of total UK residue monitoring, but for many countries was a large part of their total monitoring programme. The mean pesticide residues in Europe compare well with those in California, where regulation is stringent, the percent above the maximum residue limit (MRL) was 1.4% and 1.6% respectively, compared with the figures for all US, which show 4.8% of samples above the MRL.
    Several scientists pointed out that chemical pesticides will remain a keystone component for several decades to come in spite of the focus on biotechnology. They believe that GM will not dominate the immediate future, especially for herbicides, which is half the pesticide market. However many industry papers heavily promote biotechnology and with some important exceptions it was disappointing that there was not greater recognition of the economic and social impacts of pesticides in developing countries, and the vast potential to increase food security by more traditional and appropriate local strategies.

GT Brooks and TR Roberts (Ed), Pesticide Chemistry and Bioscience: The Food-Environment Challenge, Royal Society of Chemistry, Thomas Graham House, Cambridge, UK, Tel., +44 (0)1223 420 066, Fax, +44 (0)1223 423 429, Email sales@rsc.org, http://www.rsc.org/, 1999, 438pp. Order direct from Amazon.

 

Global residue standards  
A group of Food and Agriculture Organisation (FAO) and World Health Organisation (WHO) experts on pesticide residues in food met for its annual meeting from 21-30 September 1998 to discuss a range of issues. The report, which has now been published, summarises the current international thinking of regulators.
    The meeting evaluated 28 pesticide active ingredients, including one new compound and 18 complete re-evaluations.
    Participants assessed human dietary intakes by multiplying the residue concentrations by the average daily per capita consumption estimated for each food commodity on the basis of food diets for the Middle East, Far East, Africa, Latin America and Europe and then adding the intakes from the individual commodities. The ratio of the estimated dietary intake of pesticide residue to the corresponding acceptable daily intake (ADI) for a 60-kg person is then expressed as a percentage. Of the 18 pesticides assessed, the estimated dietary intakes exceeded the ADI in four cases: dimethoate 10-140%, disulfoton 160-920%, endosulfan 20-120% and omethoate 10-140%. This figure does not take into account gender or age differences.

Pesticide residues in food—1998, No. 148, Proceedings from a Joint Meeting of the FAO Panel of  Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues, WHO/FAO, Web http://www.fao.org/, 1999, 259pp.

 

Industry reviews OPs  
This is a review by the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) on the chronic (and other effects) of organophosphates (OPs). The small task force that produced the review contains three employees of Novartis and one each of Bayer and Rhône-Poulenc, who manufacture OPs.
    The review tries to separate the adverse effects of OPs according to whether the literature reports a previous history of acute exposure or not. The difficult issue is to establish whether long-term effects follow from repeated low-dose exposure, without any previous acute poisoning. Not surprisingly, the conclusion is that the evidence for a chronic syndrome is insufficient, but that “planned studies are followed up and the issue revisited when results are available.”
    The publication also contains a useful review of the acute and delayed effects of  OPs, noting that “OPs are potentially acutely toxic if not used as intended and according to the manufacturers’ safety instructions.” Safe use may not, however, always be possible, without much stricter controls on the availability of the products and much greater emphasis on the training of users. The report also provides information on one often neglected aspect of OP toxicity—the role of individual differences in susceptibility to OP poisoning. For such people, safe use may not be possible at all.

Organophosphorus Pesticides and Long-Term Effects on the Nervous System, Technical Report No 75, European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, December 1998, 110pp.

 

Updated WHO guidelines   
The International Programme on Chemical Safety of WHO has published the updated hazard classification guidelines in a new, clear format, which lists all pesticides according to toxicity. As in the past editions, pesticides are listed in tables: Ia extremely hazardous, Ib highly hazardous, II moderately, III slightly, or table 5 ‘pesticides unlikely to present acute hazard in normal use’. The guide also now includes a list of pesticides in the Prior Informed Consent procedure.
    There are 20 new pesticides listed, and although these are mainly in table 5, two are in Ia, one in Ib, three in II, and three in III. Included in this list is chlorfenapyr (II) which has just been refused full approval for use in the US because the Environmental Protection Agency is concerned about its toxicity to wild birds.
    According to this report, there are 576 pesticides in use, with a further 265 classified as obsolete or discontinued for use as pesticides. The number in this section has been dramatically revised, comparing with only 110 in the 1996-97 version.

WHO Recommended Classification of Pesticides by Hazard and Guidelines to Classification 1998-1999,WHO/PCS/98.21, 1999, 61pp.

 

Developing IPM in Thailand  
This report covers the proceedings of a meeting on pesticide policy reform in Thailand. It was organised by the German technical agency GTZ and the University of Hanover, in conjunction with the Food and Agriculture Organisation and included participants from a wide range of local institutions and agencies, bringing with them a vast store of experience and expertise. The focus fell on the most pressing problem: the rising level of chemical pesticide use. Thailand, like many other Southeast Asian countries, is now taking its first steps along the path of promoting a spirited public debate on the costs and benefits of pesticide use to society as a whole.
    Participants reached a broad consensus on the urgent need for a comprehensive crop protection master plan that would lead to a an IPM policy situated within the broader framework of agricultural and environmental policy. Human resources development must be considered as the heart of such a plan, especially for the integration of IPM in all activities. The main results of the workshop included:  

Nippon Poapongsakorn, Lakchai Meenakanit, Herman Weibel and Fruake Jungbluth (Eds), Approaches to Pesticide Policy Reform – Building Consensus for Future Action, A policy workshop in Hua Hin, Thailand, July 3-5, 1995, Pesticide Policy Project, Instituit für Gartenbauökonomie, Universität Hannover Fax +49 511 762 2667 and Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ), Fax +49 6196 791442, April 1999, 87pp.

 

Food facts  
The food and environment group SAFE Alliance has produced two more reports, one on soya and the other on carrots, in its Food Facts series that provide information about the negative and positive impacts of food production methods on the UK environment and society.
    Soya is in hundreds of foods from apple pies to Yorkshire puddings. Recent public concern has focused on the potential threat to the environment and human health from genetically modified soya.
    The UK imports an average of 7,000 tonnes of soya every day. This report reveals the problems which result from our dependence on this widespread and largely invisible ingredient.  
    Carrots come only second to potatoes as Britain’s most popular fresh vegetable. They can also make an excellent contribution to a healthy diet. High production levels, however, have depended on selecting heavy cropping varieties that respond well to fertilisers and that can resist pests with the help of an array of chemical pesticides.

Food Facts, No. 5 Soya, and No. 6 Carrot fashion, SAFE Alliance, 94 White Lion Street, London, N1 9PF, Fax 0171 837 1141, 1999.

 

GM publications round-up

As European concern over genetic engineering continues to mount, a number of non-governmental organisation publications have added their contributions to the debate.

Selling suicide  
GM crops are the next in a long line of inappropriate products dumped on poor countries. The UK development charity Christian Aid believes GM technology will undermine hundreds of millions of farmers in poor countries. (See also page 3 Falling into the gene trap)

Andrew Simms, Selling Suicide: farming, false promises and genetic engineering in developing countries, Christian Aid, PO Box 100, London SE1 7RT, Tel. +44 (0) 171 620 4444, Fax +44 (0) 171 620 0719, www.christian-aid.org.uk, 1999, 52pp.  

Feeding the world or fuelling hunger?  
The world’s agricultural systems are undergoing enormous change. Major corporate mergers between seed and agrochemical companies along with international legislation giving corporations more power has led to a concentration of control of the agricultural and food sectors by a handful of multinational companies.
    In this way, the UK based Action Aid says in its recent report that the multinational AstraZeneca could play a dominant role in how GM technology affects food security in developing nations (see also page 7).
    Action Aid has examined the 52 patent applications relating to GM crops made by AstraZeneca since 1993. They cover at least 90 countries world-wide, including many developing countries and many staple foods such as rice, wheat, maize, and sorghum.

AstraZenca and its genetic research: Feeding the world or fuelling hunger? Action Aid, Hamlyn House, Macdonald Road, Archway, London, N19 5PG, UK, Tel. +44 (0)171 561 7561, Fax. +44 (0)171 281 5146, http://www.actionaid.org/, 1999, 31pp. Order direct from Amazon

Order direct
from Amazon
  

Labelling will not stop GM food  
Authors Sue Dibb and Tim Lobstein of the Food Commission explain the processes that allow GM ingredients onto our food and provide comprehensive listings of brands sold in the UK that are genuinely GM free and those which are not. The book lists hundreds of foods, from organic producers, wholefood companies, leading manufacturers, caterers and fast food companies which are GM free. It will finally allow shoppers to know exactly what they are eating.

Sue Dibb and Tim Lobstein, GM Free–a shoppers Guide to Genetically Modified Food, Virgin Publishing, Thames Wharf Studios, Rainville Road, London, W6 9HT, UK, http://www.virgin-books.com/, 1999, 195pp. Order direct from Amazon.  

Hungry for power  
This book details the impact of food and agricultural transnationals on food security. Between them, the food agri-business corporations have huge control over every part of the food chain, from land to seeds, crops to chemicals, processing to marketing.
    Hungry for Power spotlights the activities of Nestlé, Cargill, Monsanto, Chiquita, Zeneca, British American Tobacco—all are charged with undermining global food security.
    Food security is too important to be left in the control of transnational corporations. The international community must take action to curb the powers of these companies.

Hungry for Power: The impact of transnational corporations on food security, UK Food Group, PO Box 100, London SE1 7RT, http://www.ukfg.org.uk/, 1999, 89pp.

  [This article first appeared in Pesticides News No. 44, June 1999, pages 22-23]