OPs on our nerves
- Study links exposure with ill-health

Campaigners calling for a ban on organophosphate (OP) sheep dips have been overwhelmingly vindicated by a recent UK government-funded report. The study, carried out by the Institute of Occupational Medicine (IOM), has concluded that the dips do cause long-term ill-health. John Harvey reports on the reaction to these latest findings.

In the largest study of its kind so far, researchers found that exposure to concentrated sheep- dip is most likely to cause nerve damage and that splashes from the diluted product are also a threat to farmers' health.
   
The study focused on working farmers: it has not included those whose health has already been devastated by sheep-dip. Continued exposure may cause long-term illness.
   
Findings of the long-awaited IOM report include:

Reaction to the report
Farmers and campaigners may hold a rally later this year to protest against the lack of government action on OP chemicals.
   
Although the report found that farmers did suffer damage from long term exposure to low doses of OP dip, the government has so far refused to make any radical changes in the marketing or use of dips. Instead, Ministers have accepted advice from the Veterinary Products Committee (VPC), the Veterinary Medicines Directorate (VMD) and the Health and Safety Executive (HSE) that dips are safe to use.
   
In a letter sent to farmers after the report was published, the HSE and VMD said: "The IOM study observed that dippers handling concentrate were not following the recommended safety precautions and, in particular, that the recommended gloves were not being worn or not being used properly." One farmer who received the letter described it as "rubbish. There was one sentence in the whole IOM study on gloves," said Gary Coomber, who used to dip sheep on his Kent farm. "They are trying to push the onus back on the farmer when they know the protective clothing specified is not adequate, and never will be."
   
Another letter about the report from Professor Liam Donaldson, the Chief Medical Officer, invited doctors with patients suffering from symptoms of peripheral neuropathy nerve damage to refer them to a consultant neurologist or to "discuss the case with medical staff within the National Poisons Information Service." Elizabeth Sigmund, co-ordinator of the OP Information Network (OPIN) dismissed the letter as " ... next to useless. The only way to bring this out into the open is to have an international conference. There are OP experts in Europe and work is being done in the United States: we need to hear from these people." Earlier this year, OPIN's application to fund a conference was turned down by the European Commission's environment directorate.
   
Owen Tudor, senior policy officer for health and safety, at the Trades Union Congress (TUC) has had discussions with OPIN about this. "In some ways, the report is just another brick in the wall rather than the main breakthrough," said Mr Tudor. "It was greeted by the regular refrain that more research is needed, but that point was passed some time ago." TUC policy is that OP sheep dipping should be banned.
   
Mr Tudor is a member of the Health and Safety Commission-the HSE's parent organisation-which has discussed the IOM report and should be giving more advice to Ministers soon. A working party of the Committee on Toxicity chaired by Professor Frank Woods will also examine the IOM work before publishing its own report on OPs. The VPC-which advises Ministers on OPs-has provoked a row by insisting on re-examining some of the data used to compile the IOM report. VPC chairman Professor Ian Aitken confirmed the VPC's medical and scientific panel had already begun the work. When he was asked why the VPC wanted another look, Professor Aitken said: "We need to try to get the maximum information possible out of the original data."
   
Dr Goran Jamal, a consultant neurologist who co-wrote the IOM report, said the VPC's reaction was absurd. "This project was discussed by the VPC sub committee responsible for assessing research in 1995." After that, there was 'step-by-step approval' by a Government steering committee on which the VPC was represented. "I did not think anyone from the VPC would have the nerve to raise objections, because they were part of the study," said Dr Jamal, who is at the West London Regional Neuro-Science Centre, part of Imperial College's school of medicine.
   
There are three reasons why the report should not be forgotten, said Dr Jamal. Firstly, taxpayers had spent £500,000 on the study. "Chemical companies make big profits from selling these compounds, but haven't funded independent research in this area." Secondly, the implications of the report went beyond farming. "From a scientific and clinical point of view, if one occupational group is being affected, there's no reason why others won't be as well." Thirdly, in the light of BSE and concern about genetically modified organisms (GMOs), there should be a re-examination of the advice given to Ministers by scientific committees. "Since 1992, two or three scientists, saying there is evidence that OPs cause damage, have been dismissed by people from within the committee structures. Now those same people have been proved wrong."
   
The report has also raised concerns in the US. Congressman Christopher Shays represents Connecticut for the Republicans. He chairs the committee on national security, veterans affairs and international relations, a sub-committee of the House Government Reform Committee. He has been concerned about Gulf War veterans exposed to OPs, and saw the IOM report. His spokesman told Pesticides News: "We are very concerned about the role of OPs in either causing or contributing to nerve damage. As a result of our research into Gulf War illness, there have been studies by the Institute of Medicine-as required by the Veterans Health Bill which Congressman Shays has helped to pass. We feel the veterans' administration is doing all it can to research OPs."

Pesticides Trust [now PAN UK] comment
This report has produced significant findings that should be taken seriously by regulatory authorities. Medical resources should now be directed towards diagnosing and treating the victims, and a regime of no-fault liability should be introduced so that they are compensated as soon as possible.
   
There are important international implications from this study. OPs are widely used in developing countries in situations where exposure can be much higher than the UK. Regulatory restriction in the UK would send the right signals abroad and possibly facilitate similar action in developing countries.
   
"The safety of all OPs is now in question", concluded Peter Beaumont of the Pesticides Trust. "These are highly dangerous chemicals and we should not be using them."

Epidemiological study of the relationships between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy, and neuropsychological abnormalities in sheep farmers and dippers, Institute of Occupational Medicine, May 1999. Copies of the report available from Fintan Hurley, Director of Research Quality, +44 (0)131 667 5131.

John Harvey is a broadcaster and writer on farming issues.

[This article first appeared in Pesticides News No. 45, September 1999, page 3]